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Home BPharma Physics Pharmaceutics I To prepare 10 ml of paracetmol pediatric elixir
Physics Pharmaceutics I Lab Experiments

To prepare 10 ml of paracetmol pediatric elixir



Aim

To prepare 10 ml of paracetmol pediatric elixir.

Apparatus Required:

Beakers, glass rod, measuring cylinder.

Category:Analgesic and antipyretic

Formula:

S. No. Ingredients Official Formula(I.P.)
1 Paracetmol 2.4 gm
2 Ethanol (96%) 10ml
3 Chloroform water 2 ml
4 Syrup 28 ml
5 Glycerin q. s. to 100ml

Principle:

Elixirs are flavored hydro alcoholic solutions to which glycerin often is added to enhance the solvent properties. The alcohol which is present in the chloroform spirit act as a preservative. Paracetmol is unpleasant taste which is masked with the syrup to prevent the unpleasant taste of elixir. The addition of aqueous solutions to elixirs may cause turbidity or separation by lessening the alcohol concentration.

Procedure:

Dissolve the Paracetmol in the mixture of ethanol and chloroform water. Then add the syrup with continuous stirring and shake it. Finally add the glycerin to make up the final volume.

Dispensing:

Transfer the elixir to a clear or amber colored, narrow mouthed glass bottle, close it thoroughly with metallic screw cap, polish and label.

Storage:

Store in a closed container at a temperature not exceeding 250C.

Direction:

5-10ml daily in divided doses to be taken in morning and night.

Note:The term Analgesics encompasses a class of drugs that are designed to relieve pain without causing the loss of consciousness.